Stem Cells for Cutaneous Wound Healing

Stem Cells for Cutaneous Wound Healing

Optimum healing of a cutaneous wound involves a well-orchestrated cascade of biological and molecular processes involving cell migration, proliferation, extracellular matrix deposition, and remodelling. When the normal biological process fails for any reason, this healing process can stall resulting in chronic wounds. Wounds are a growing clinical burden on healthcare systems and with an aging ...

Amniotic Fluid Stem Cells for Wound Healing

A. Atala and S.V. Murphy (eds.), Perinatal Stem Cells, DOI 10.1007/978-1-4939-1118-9_2, © Springer Science+Business Media New York 2014 Abstract Amniotic fl uid-derived stem (AFS) cells are an attractive cell source for applications in regenerative medicine due to their proliferation capacity, multipotency, immunomodulatory activity, and lack of signifi cant immunogenicity. In addition, they ha...

Mast Cells in Cutaneous Wound Healing

Mast cells are suggested to participate in wound healing, but their specific role has remained obscure. Mast cells are a rich source of inflammatory mediators, such as histamine, proteoglycans, the proteases tryptase and chymase, lipids, growth factors and cytokines. Among these mediators, there are many that have effects on cell growth, tissue turnover and repair. The aim of this study was to ...

Cutaneous wound healing

Therapeutic potential of bone marrow-derived mesenchymal stem cells for cutaneous wound healing

Despite advances in wound care, many wounds never heal and become chronic problems that result in significant morbidity and mortality to the patient. Cellular therapy for cutaneous wounds has recently come under investigation as a potential treatment modality for impaired wound healing. Bone marrow-derived mesenchymal stem cells (MSCs) are a promising source of adult progenitor cells for cytoth...